What is the detection method and clinical significance of cystatin C? In order for everyone to have a better understanding, the editor has organized the content. Let's take a look together.
Also known as cysteine protease inhibitor protein C, it is an endogenous alkaline non glycosylated protein with a molecular weight of approximately 13kD.
CysC production rate is stable and can be completely filtered by the glomerulus. It is completely reabsorption in the proximal convoluted tubule and rapidly metabolized.
CysC does not form complexes with other proteins, and its serum concentration changes are not affected by factors such as inflammation, infection, tumors, and liver function. It is not related to gender, diet, body surface area, or muscle mass, and is an ideal endogenous marker that reflects changes in GFR.
[Detection Method]
Blood CysC is often detected using latex particle enhanced immunoturbidimetry.
Reference interval
Adult blood CysC is 0.6-2.5mg/L.
Clinical significance
The blood CysC concentration is highly correlated with the degree of renal function damage, and can accurately reflect changes in human GFR. When monitoring renal function, it is a sensitive indicator that can detect early renal function damage.
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